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problem in permanently storing new long-term memories) One potential drawback to this approach is that because of variability in the criteria used for group classi cation, it is sometimes dif cult to make comparisons across studies For this reason it has become customary in recent years to provide more operational criteria that can be used to assign patients to groups For an example of how this has been accomplished in research on amnesia, see Squire and Shimamura (1986) In recent years, controversy has existed about the relative utility of group versus single-case studies in facilitating progress in clinical neuropsychology Some have argued that both single-case and group studies are appropriate in neuropsychological research, whereas others argue that only single-case studies promote reliable inferences into cognitive structure (McCloskey, 1993; Shallice, 1988) Those who contend that only single-case studies are appropriate criticize group research on a number of grounds.

1. Open a video file. 2. Choose Window Animation to display the Animation (Timeline) palette if you don t already have it displayed.

One criticism is based on the use of syndromes, or collections of clinical symptoms, as a basis for group classi cation Cognitive symptoms can co-occur after damage to the brain because they (a) are each based on the same underlying cognitive mechanism, or (b) depend on regionally adjacent brain structures or systems The argument against group research is that if one studies a syndrome based on the situation described previously in (b), one runs the risk of confusing functional and structural associations If such symptoms are related simply through regional proximity, studying them with cognitive methods may tell us little about underlying functional architecture This is an in-principle argument that many neuropsychologists believe applies in general to all syndromes used for group classi cation (Coltheart, 2001).

Proponents of this argument suggest that although the study of syndromes is a useful rst step in de ning what cognitive processes might be involved in the de cit, real progress is made only through the analysis of individual cases An additional problem with group research is that even when patients are grouped in order to be homogeneous with respect to the presence of a localized lesion, they may be behaviorally heterogeneous with respect to the cognitive process under study (Gazzaniga, Ivry, & Mangin, 1998) It is widely known that individual data cannot be derived from an exclusive study of average scores (Sidman, 1952) Thus, even though we are capable of generating point estimates of central tendency (eg, means, medians, modes) from group data, the individual data points or curves might be quite heterogeneous with respect to these estimates.

This heterogeneity might result, for example, from subtle individual differences in brain organization or in the degree of functional compensation Thus, despite the fact that a group of.

represents the true linear relationship between nutritional rating and sugar content for all cereals, not just those in our sample. The error term is needed to account for the indeterminacy in the model, since two cereals may have the same sugar content but different nutritional ratings. The residuals (yi y ) are estimates of the error terms, i , i = 1, . . . , n. Equation (2.1) is called the regression equation or true population regression equation; it is associated with the true or population regression line. Earlier, we found the estimated regression equation for estimating the nutritional rating from sugar content to be y = 59.4 2.42(sugar s). Where did these values for b0 and b1 come from Let us now derive the formulas for estimating the y-intercept and slope of the estimated regression line given the data. Suppose that we have n observations from the model in equation (2.1); that is, we have yi = 0 + 1 xi + i i = 1, . . . , n

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Neuropsychology focuses on brain-behavior relationships. These are defined as how brain functioning impacts behavior and behavioral problems. Neuropsychologists assess brain and behavioral functioning and offer strategies for patients suffering from brain impairment due to a large range of problems such as dementia, head injuries, tumors, autism, stroke,